KMID : 0359320210610030021
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Korean Journal of Veterinary Research 2021 Volume.61 No. 3 p.21 ~ p.21
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CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/CD45-/CD79a-/TCR¥á¥â+/TCR¥ã¥ä-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: a case report
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Shin Sun-Woo
Lim Yu-Jin Bae Hyeon-A Kim Ji-Hu Cho A-Rom Park Jin-Ho Lee Dong-Bin Jung Dong-In Kim Sang-Ki Yu Do-Hyeon
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Abstract
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Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCR¥á¥â, and MHCII but negative for CD34, CD45, CD79a, and TCR¥ã¥ä. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.
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KEYWORD
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lymphoma, flow cytometry, immunophenotyping, dog, case report
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